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KMID : 0861020020170010093
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Korea Journal of Herbology
2002 Volume.17 No. 1 p.93 ~ p.111
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Effects of Hyulbuchukeotang and its component groups on diabetes , free radical and antioxidative defense system in alloxan - induced diabetic rats
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Abstract
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This study was reseached to investigate the effect of Hyulbuchukeotant(?????) and its component groups on diabetes, free radical and antioxidative defense system in alloxan-induced diabetic rats, The experimental group was divided into three groups: Hyulbuchukeotang (HCT), and its components groups, Sayeoksan(H-sa) and Dohong- samultant(H-do).
The results were obtained as follows:
In the study of effect on diabetes, the level of glucose was considerablely reduced by HCT, H-sa and H-do with high significancy. In the change of fat metabolism, all experimental groups significantly changed the level of triglyceride, total cholesterol and HDL cholesterol expecially HCT and H-do group, but H-sa group has less significancy. In the change of protein metabolism, all experimental groups changed the level of total protein and albumin with high significancy. In the change of kidney function, HCT decreased the level of creatinine and BUN with high significancy, H-sa and H-do did with some significancy too.
In the study on free radical scavenging effect in vitro, it has shown that all experimental groups have significant suppressing effect on peroxidation of linoleic acid on concentration, and in the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and inhibitory effect on lipid peroxidation reaction by hydroxy radical in H₂O₂-Fe^2+ system, all experimental groups have some activity.
In the study on antioxidative defense system in vivo, HCT reduced the amount of lipid peroxide in serum and liver with high significantcy, and H-sa, H-do group did too with some significancy. In hepatic catalase activity, all experimental groups had showed activity on catalase, but H-sa no significancy. In the level of hepatic hlutathione, HCT increased the amount of glutathione significantly, but other groups with no significancy. In the activity of glutathione-s-transferase, all experimental groups has decreasing effect with significancy.
These results suggest that Hyulbuchukeotant(?????) has strong effect on diabetes and peroxidative damage by free radical, so it is useful to prevent diabetes.
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KEYWORD
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